公表論文リスト


  • 63 Kazunari, Hashiguchi and Q-M, Zhang-Akiyama
    Establishment of Human Cell Lines Lacking Mitochondria DNA
    Methods in Molecular Biology Book 2009 In press


  • 62 Q-M, Zhang-Akiyama, H,Morinag, M,Kikuchi, S-I,Yonekura, H, Sugiyama, K,Yamamoto and S, Yonei
    KsgA, a 16rRNA transferees protein has a DNA-glycosylase/AP lyase activity to prevent mutations in Escherichia coli
    Nucleic Acid Research 37 2009 Advance Access published February 17 >PubMed


  • 61 M,Takao,M, Y, Oohata, K, Kitadokoro, K, Kobayashi, S, Iwai, A, Yasui, S, Yonei and Q-M, Zhang
    Human Nei-like protein NEIL3 has AP lyase activity specific for single-strand DNA and confers oxidative stress resistance in Escherichia coli mutant
    Genes to cells 14 261-270 2009


  • 60 S-I,Yonekura, N, Nakamura, S, Yonei and Q-M, Zhang-Akiyama
    Generation, Biological Consequences and Repair mechanisms of Cytosine Deamination in DNA
    Journal of Radiation Research 50 19-26 2009 >PubMed


  • 59 Li-Li, Wang and Q-M, ZHANG
    Primary research of human anti-oxidation gene GLRX2 and TXN1
    Journal of Biology 25, 17-20 2008


  • 58 Nobuya Nakamura, H,Morinaga, M.Kikuchi, S,Yonekura, K, Yamamoto,A, Ishii, S, Yonei and Q-M, Zhang
    Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans
    Mutagenesis 23 407-413 , 2008 >PubMed


  • 57 S-I. Yonekura, T. Doi, N. Nakamura, S. Yonei, H. Sugiyama and Q-M. Zhang
    Base excision repair of 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group in DNA by Schizosaccharomyces pombe Nth1
    Journal of Radiation Research Vol. 48 (2007) , No. 5 417-424 >PubMed


  • 56 中村允耶、米倉慎一郎、森永浩伸、米井脩治、張秋梅
    シトシン脱アミノ化の生物作用とその修復の機構
    42(2), 2007, 132-146 ; 放射線生物研究 >Homepage


  • 55 Katie Chan, Q-M, Zhang, I. Hickson and G.L. Dianov
    Overexpression of DNA polymerase b results in increased rates of frameshift mutations during base excision repair
    Mutagenesis 22 1-6 2007 >PuBMed


  • 54 Katie K. L. Chan, Q-M, Zhang and G.L. Dianov
    Base excision repair fidelity in normal and cancer cells
    Mutagenesis 21 173-178 2006 > PubMed


  • 53 G. Jin, Q-M. Zhang, Y, Satou, N.Satoh, H. Kasai, and S. Yonei
    Cloning and characterization of an ascidian homolog of the human 8-oxoguanine DNA glycosylase(Ogg1) that is involved in the repair of 8-oxoguanine in DNA in Ciona intestinalis
    Int. J. Radiat. Biol. 82 241-250 2006 > PubMed


  • 52 張秋梅、米井脩治
    定常強磁場暴露による活性酸素の増産と突然変異の誘発  
    電磁場生命科学（宮越順二編）、京大出版会、京都 Book   2005  


  • 51 張　秋梅
    放射線や活性酸素でDNAに生じる酸化的塩基損傷の生物作用と修復機構
    放影協ニュース 44 5-7 2005  


  • 50 張　秋梅、米倉慎一郎、中村允耶、金貴花、米井脩治
    塩基除去修復の構成とヒトDNA グリコシラーゼの機能
    放射線生物研究 40 185-201 2005 >放射線生物研究


  • 49 T. Doi, S.Yonekura, K.Tano, S.Yasuhira, S. Yonei and Q.-M. Zhang
    The Shizosaccharomyces pombe homolog (SpMYH) of the Escherichia coli MutY is required for removal of guanine from 8-oxoguanine/guanine mispairs to prevent G:C to C:G transversions
    J. Radiat. Res. 48 205-214 2005 >PubMed


  • 48 P.-W. Chang, Q.-M. Zhang, K. Takatori, A. Tachibana and S. Yonei
    Increased sensitivity to sparsely ionizing radiation due to excessive base excision in clustered DNA damage sites in Escherichia coli
    Int. J. Radiat. Biol. 81 115-123 2005 >PubMed


  • 47 張秋梅、中村允耶、米倉慎一郎、 米井脩治
    DNA酸化への防御戦略―塩基除去修復を中心に
    蛋白質・核酸・酵素 50 322-329 2005 >PubMed


  • 46 Q.-M. Zhang and G. L. Dianov
    DNA repair fidelity of base excision repair pathways in human cell extracts
    DNA Repair 4 263-270 2005 >PubMed


  • 45 Q.-M. Zhang, S. Yonekura, M. Takao, A. Yasui, H. Sugiyama and S. Yonei
    DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells
    DNA Repair   4 71-79 2005 >PubMed


  • 44 H. Hirose, T. Nakahara, Q.-M. Zhang, S. Yonei and J. Miyakoshi
    Static magnetic field with a strong magnetic field gradient (41.7 T/m) induces c-Jun expression in HL-60 cells
    In Vitro Cell. Dev. Biol. 39 348-392 2003 >PubMed


  • 43 M. Yahiro-Takata, Y. Fujii, J. Fraga, S.Oda, Q.-M. Zhang, S. Yonei and M. Nakamura
    A novel GT-mismatch binding protein that recognizes strict sequences with high affinity  
    Tohoku J. Exp. Med. 200 211-229 2003 >PubMed


  • 42 Q.-M. Zhang, K. Hashiguchi, K. Kino, H. Sugiyama and S. Yonei
    Ntg1 and Ntg2 proteins as a 5- formyluracil-DNA glycosylase/AP lyase in Saccharomyces cerevisiae
    Int. J. Radiat. Biol. 79 341-349 2003 >PubMed


  • 41 Q.-M. Zhang, M. Tokiwa, T. Doi, P.-W. Chang, N. Nakamura, J. Miyakoshi and S. Yonei
    Strong static magnetic field induces mutations through elevated production of reactive oxygen species in Escherichia coli soxR
    Int. J. Radiat. Biol. 77 53-58 2003 > PubMed


  • 40 M. Hori, S. Yonei, H. Sugiyama, K. Kino, K. Yamamoto and Q.-M. Zhang
    Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases
    Nucleic Acids Res. 31 1191-1196 2003 >PubMed


    • repair.png(43453 byte)



  • 39 M. Takao, S. Kanno, K. Kobayashi, Q.-M. Zhang, S. Yonei, G. T. J. Horst and A. Yasui
    Mammalian Nei1 is a novel DNA glycosylase for backup repair of oxidative damage in Nth1-knockout mice
    J. Biol. Chem. 277 42205- 42213 2002 >PubMed


  • 38 米井脩治、張秋梅
    低線量の健康影響―低線量放射線の生物影 響と細胞応答―
    日本放射線技術学会雑誌 58 1328-1334 2002 >PubMed


  • 37 I. Miyabe, Q.-M. Zhang, K. Kino, H. Sugiyama, M. Takao, A. Yasui and S. Yonei
    Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein  
    Nucleic Acids Res. 30 3443-3448 2002 >PubMed


  • 36 K. Hashiguchi, Q.-M. Zhang, H. Sugiyama, S. Ikeda and S. Yonei
    Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein
    Int. J. Radiat. Biol. 78 585-592 2002 >PubMed


  • 35 Q.-M. Zhang
    Role of the Escherichia coli and human DNA glycosylases that remove 5- formyluracil from DNA in the prevention of mutations
    J. Radiat. Res. 42 11-19 2001 >PubMed


  • 34 米井脩治、張秋梅
    低線量放射線の健康影響: 低線量の影響と細胞応答
    日本放射線防護学会会誌 13 4-6 2001  


  • 33 Y. Matsumoto, Q.-M.Zhang, M. Takao, A. Yasui and S. Yonei
    Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8- oxoguanine/guanine mispairs in DNA
    Nucleic Acids Res. 29 1975-1981 2001 >PubMed


  • 32 I. Miyabe, II. Q.-M. Zhang, K. Kino, H. Sugiyama and S. Yonei
    Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli
    Int. J. Radiat. Biol. 77 54-58 2001 >PubMed


  • 31 Q.-M. Zhang, I. Miyabe, Y. Matsumoto, K. Kino, H. Sugiyama and S. Yonei
    Identification of repair enzymes for 5- formyluracil in DNA: Nth, Nei and MutM proteins of Escherichia coli  
    J. Biol. Chem. 275 35471- 35477 2000 >PubMed


  • 30 Q.-M. Zhang, I. Miyabe, K. Hashiguchi and S. Yonei
    Some features of base excision repair and its role in prevention of spontaneous and radiation-induced mutations  
    Free Radicals in Chemistry, Biology and Medicine (Ed. T. Yoshikawa, J. Yamamoto, Y. Naito and S. Toyokuni), OICA, London Book 248-256 2000  


  • 29 I. Miyabe, Q.-M. Zhang, Y. Kano and S. Yonei
    Histone-like protein HU is required for recA gene-dependent DNA repair and SOS induction pathways in UV- irradiated Escherichia coli
    Int. J. Radiat. Biol. 76 43-49 2000 >PubMed


  • 28 T. Nakahara, Q.-M. Zhang and S. Yonei
    Identification of proteins of Escherichia coli and Saccharomyces cerevisiae that specifically bind to C/C mismatches in DNA
    Nucleic Acids Res. 28 2551-2556 2000 >PubMed


  • 27 Q.-M. Zhang, A. Tachibana and S. Yonei
    Oxygen stress model: E. coli, cultured cells  
    Experimental Protocols for Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) (Edited by N. Taniguchi and J. M. C. Gutteridge), Oxford University Press, London Book 316-319 2000  


  • 26 Q.-M. Zhang, H. Sugiyama, I. Miyabe, S. Matsuda, K. Kino, I. Saito and S. Yonei
    Replication in vitro and cleavage by restriction endonuclease of 5-formyluracil- and 5-hydroxymethyl- uracil-containing oligonucleotides
    Int. J. Radiat. Biol. 75 59-65 1999 >PubMed


  • 25 M. Takao, Q.-M. Zhang, S. Yonei and A. Yasui
    Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8- oxoguanine DNA glycosylase
    Nucleic Acids Res. 27 3638-3644 1999 >PubMed


  • 24 張秋梅、松本由記子、米井脩治
    大腸菌の MutM, MutY タンパク質の構造と機能
    放射線生物研究 34 303-314 1999  


    • hammer.jpg(18652 byte)



  • 23 Q.-M. Zhang, N. Ishikawa, T. Nakahara and S. Yonei
    Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine: guanine mispair to prevent spontaneous G:C- C:G transversions
    Nucleic Acids Res. 26 4669-4675 1998 >PubMed


  • 22 T. Takemoto, Q.-M. Zhang and S. Yonei
    Different mechanisms of thioredoxin in its reduced and oxidized forms in defense against hydrogen peroxide in Escherichia coli
    Free Radical Biol. Med. 24 556-562 1998 >PubMed


  • 21 T. Takemoto, Q.-M. Zhang, Y. Matsumoto, S. Mito, T. Izumi, H. Ikehata and S. Yonei
    3’-Blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Escherichia coli  
    J. Radiat. Res. 39 137-144 1998 >PubMed


  • 20 Q.-M. Zhang, H. Sugiyama, I. Miyabe, S. Matsuda, I. Saito and S. Yonei
    Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA
    Nucleic Acids Res. 25 3969-3973 1997 >PubMed


  • 19 米井脩治、張秋梅、松本由記子、中原岳久
    酸化ストレスと細胞制御:生物のパラドックス
    放射線生物研究 32 87-104 1997  


  • 18 Q.-M. Zhang, S. Mito, T. Takemoto and S. Yonei
    Induction of repair capacity for oxidatively damaged DNA as a component of peroxide stress in Escherichia coli
    J. Radiat. Res. 37 171-175 1996 >PubMed


  • 17 H. Sugiyama, S. Matsuda, Q.-M. Zhang, S. Yonei and I. Saito
    New synthetic method of 5- formyluracil-containing oligonucleotides and their melting behavior
    Tetrahedron Lett. 37 9067-9070 1996 >PubMed


  • 16 米井脩治、張秋梅
    活性酸素の代謝  
    活性酸素と医食同源−分子論的背景と医食の接点を求めて (井上正康編)、 共立出版、東京 Book 50-56 1996  


  • 15 Q.-M. Zhang, T. Takemoto and S. Yonei
    The sensitivity of three soi mutants of Escherichia coli to oxidizing mutagens
    Environ. Mutagen Res. 16 397-402 1995 >PubMed


  • 14 Q.-M. Zhang, J. Fujimoto and S. Yonei
    Enzymatic repair of 5-formyluracil in DNA caused by ionizing radiation in cell extract from mouse liver
    Int. J. Radiat. Biol. 68 603-607 1995 >PubMed


  • 13 米井脩治、張秋梅
    酸化的ストレスによる遺伝子発現とその制御
    環境変異原研究 16 345-355 1995  


  • 12 張秋梅、米井脩治
    ス−パ−オキシド誘導性遺伝子とその発現制御
    放射線科学 38 46-50 1995  


  • 11 米井脩治、張秋梅、竹本 忠司
    酸素ストレスモデル  
    細胞工学別冊「活性酸素実験プロトコル」(谷口直之編)、 秀潤社, 東京   311-316 1995  


  • 10 米井脩治、張秋梅
    抗酸化ストレス機構研究の現状
    最新医学 49 2260-2266 1994  


  • 9 S. Yonei, Q.-M. Zhang and T. Takemoto
    Isolation and characterization of Escherichia coli strains containing new gene fusions inducible by superoxide stress
    Frontiers of Reactive Oxygen Species in Biology and Medicine (Ed. K. Asada and T. Yoshikawa) Elsevier, Amsterdam Book 277-278 1994  


  • 8 Q.-M. Zhang, T. Takemoto and S. Yonei
    Molecular cloning and characterization of new members of the soxRS regulon in Escherichia coli
    Frontiers of Reactive Oxygen Species in Biology and Medicine (Ed. K. Asada and T. Yoshikawa) Elsevier, Amsterdam Book 281-282 1994  


  • 7 T. Takemoto, Q.-M. Zhang and S. Yonei
    Isolation and characterization of new soi genes inducible by superoxide radicals in Escherichia coli K12  
    Frontiers of Reactive Oxygen Species in Biology and Medicine (Ed. K. Asada and T. Yoshikawa) Elsevier, Amsterdam Book 279-280 1994  


  • 6 張秋梅、竹本忠司、米井 脩治
    酸素ストレス応答の発現と遺伝子制御  
    放射線生物研究 29 261-274 1994  


  • 5 S. Mito, Q,-M. Zhang and S. Yonei
    Isolation and characterization of Escherichia coli strains containing new gene fusions (soi::lacZ) inducible by superoxide radicals
    J. Bacteriol. 175 2645-2651 1993 >PubMed


  • 4 S. Yonei and Q.-M. Zhang
    Regulation of gene expression by oxygen stress in Escherichia coli and mammalian cells
    Jap. J. Freezing Drying 39 83-89 1993  


  • 3 Q.-M. Zhang, S. Yonei and M. Kato
    Multiple pathways for repair of oxidative damages induced by ionizing radiation and hydrogen peroxide in Escherichia coli
    Radiat. Res. 132 334-338 1992 >PubMed


  • 2 Q.-M. Zhang and S. Yonei
    Induction of manganese superoxide dismutase by membrane-binding drugs in Escherichia coli
    J. Bacteriol. 173 3488-3491 1991 >PubMed


  • 1 米井脩治、張秋梅、 水戸誠二
    光に対する生物の適応現象
    遺伝 45 55-59 1991